Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules
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چکیده
منابع مشابه
Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules
The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing spondylitis (AS) and Reactive Arthritis (ReA), has been well established and remains the strongest association between any HLA molecule and autoimmune disease. The mechanism behind this striking association remains elusive; however animal model a...
متن کاملGenetic modulation of antigen presentation by HLA-B27 molecules
In studies of antigenic peptide presentation, we have found a healthy volunteer whose lymphoblastoid cells were unable to present three different virus-derived epitopes to cytotoxic T lymphocytes (CTL) despite expressing the correct restricting HLA-B27 molecules on the cell surface. B cell lines were established from other members of the donor's family, including individuals suffering from anky...
متن کاملEDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated degradation
David Guiliano, Izabela Lenart, Edward Tsao, Nasim Yousaf, Paul Kellam, Greg Towers and Antony N. Antoniou, Division of Infection and Immunity/Centre of Rheumatology, Rayne Building, 5 University Street, University College London, London, WC1E 6JF School of Health, Sport and Bioscience, University of East London, London, E15 4LZ Helen Fussell, Histocompatibility and Immunogenetics Department, N...
متن کاملHLA-B27: what's new?
The HLA-B27 molecule is one of the most fascinating in medicine. Its contribution to the aetiopathogenesis of SpA and other diseases, and its protective action in certain infections, continue to challenge our understanding of its immunobiology and physiological roles. Animal studies have helped to cast light on ways in which HLA-B27 exerts its effects. Subtle variations in structure and behavio...
متن کاملHLA-B27 and Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a chronic inflammatory disease with potential disabling outcomes. Clinically, patients presented with inflammatory lower back pain, enthesis and alternated buttock pain (van der Linden & van der Heijde, 1998). Bernard Corner (16661698) was the first physician who published the clinical features of AS in his medical thesis (Baker & Weisman, 2006). In the late 19th ...
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ژورنال
عنوان ژورنال: International Journal of Rheumatology
سال: 2011
ISSN: 1687-9260,1687-9279
DOI: 10.1155/2011/486856